2. Others Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Endogenous Metabolite GlyT
  4. N-Arachidonylglycine-d8

N-Arachidonylglycine-d8  (Synonyms: NA-Gly-d8)

Cat. No.: HY-103332S Purity: 98.1%
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Handling Instructions Technical Support

N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine. N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

For research use only. We do not sell to patients.

N-Arachidonylglycine-d<sub>8</sub> Chemical Structure

N-Arachidonylglycine-d8 Chemical Structure

CAS No. : 1159908-44-7

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1 mg (2.71 mM * 1 mL in Ethanol) Get quote 2-4 weeks 2-4 weeks 2-4 weeks

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Arachidonylglycine-d8:

N-Arachidonylglycine-d8 Related Antibodies

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Description

N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine[1]. N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells[2].
N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Arachidonylglycine-d8 Related Antibodies
In Vivo

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold[4].
N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

369.57

Formula

C22H27D8NO3
CAS No.
Unlabeled CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(CNC(CCC/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\C/C([2H])=C([2H])\CCCCC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (135.29 mM; Need ultrasonic)

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.1%

SDS (251 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.7058 mL 13.5292 mL 27.0585 mL 67.6462 mL
5 mM 0.5412 mL 2.7058 mL 5.4117 mL 13.5292 mL
10 mM 0.2706 mL 1.3529 mL 2.7058 mL 6.7646 mL
15 mM 0.1804 mL 0.9019 mL 1.8039 mL 4.5097 mL
20 mM 0.1353 mL 0.6765 mL 1.3529 mL 3.3823 mL
25 mM 0.1082 mL 0.5412 mL 1.0823 mL 2.7058 mL
30 mM 0.0902 mL 0.4510 mL 0.9019 mL 2.2549 mL
40 mM 0.0676 mL 0.3382 mL 0.6765 mL 1.6912 mL
50 mM 0.0541 mL 0.2706 mL 0.5412 mL 1.3529 mL
60 mM 0.0451 mL 0.2255 mL 0.4510 mL 1.1274 mL
80 mM 0.0338 mL 0.1691 mL 0.3382 mL 0.8456 mL
100 mM 0.0271 mL 0.1353 mL 0.2706 mL 0.6765 mL
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N-Arachidonylglycine-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Arachidonylglycine-d81159908-44-7NA-Gly-d8Isotope-Labeled CompoundsEndogenous MetaboliteGlyTGlycine transportersInhibitorinhibitorinhibit

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