2. PI3K/Akt/mTOR Stem Cell/Wnt Cell Cycle/DNA Damage
  3. GSK-3 CDK
  4. (E/Z)-BIO-acetoxime

(E/Z)-BIO-acetoxime  (Synonyms: GSK-​3 Inhibitor X)

Cat. No.: HY-114903 Purity: 99.0%
COA
SDS
Handling Instructions Technical Support

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM).

For research use only. We do not sell to patients.

(E/Z)-BIO-acetoxime

(E/Z)-BIO-acetoxime Chemical Structure

CAS No. : 740841-15-0

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Based on 1 publication(s) in Google Scholar

Other Forms of (E/Z)-BIO-acetoxime:

(E/Z)-BIO-acetoxime Related Antibodies

Top Publications Citing Use of Products

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GSK-3 GSK-3α GSK-3β

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].

IC50 & Target[1]

GSK-3α

10 nM (IC50)

GSK-3β

10 nM (IC50)

Cdk5/p25

2.4 μM (IC50)

CDK2/cyclinA

4.3 μM (IC50)

CDK1/cyclinB

63 μM (IC50)

In Vitro

E/Z)-BIO-acetoxime (compound 13) shows more than 200-flod selectivity for GSK-3α/β over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B, with IC50s of 0.01, 2.4, 4.3 and 63 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E/Z)-BIO-acetoxime Related Antibodies
Molecular Weight

398.21

Formula

C18H12BrN3O3
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C\3C=CC(Br)=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.0%

SDS (419 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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(E/Z)-BIO-acetoxime Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-BIO-acetoxime740841-15-0GSK-​3 Inhibitor XGSK-3CDKGlycogen synthase kinase-3Glycogen synthase kinase 3Cyclin dependent kinaseInhibitorinhibitorinhibit

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