2. Others Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor Isotope-Labeled Compounds
  4. Darolutamide-d4

Darolutamide-d4  (Synonyms: ODM-201-d4; BAY-1841788-d4)

Cat. No.: HY-16985S Purity: 98.58%
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Darolutamide-d4 (ODM-201-d4) is deuterium labeled Darolutamide. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay.

For research use only. We do not sell to patients.

Darolutamide-d<sub>4</sub>

Darolutamide-d4 Chemical Structure

CAS No. : 2484757-20-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Darolutamide-d4:

Darolutamide-d4 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Darolutamide-d4 (ODM-201-d4) is deuterium labeled Darolutamide. Darolutamide (ODM-201;BAY-1841788) is a potent androgen receptor (AR) antagonist with an IC50 of 26 nM in in vitro assay[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Darolutamide-d4 Related Antibodies
Molecular Weight

402.87

Formula

C19H15D4ClN6O2
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NNC(C([2H])(O)C([2H])([2H])[2H])=C1)N[C@@H](C)CN2N=C(C3=CC=C(C#N)C(Cl)=C3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4822 mL 12.4110 mL 24.8219 mL
5 mM 0.4964 mL 2.4822 mL 4.9644 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4822 mL 12.4110 mL 24.8219 mL 62.0548 mL
5 mM 0.4964 mL 2.4822 mL 4.9644 mL 12.4110 mL
10 mM 0.2482 mL 1.2411 mL 2.4822 mL 6.2055 mL
15 mM 0.1655 mL 0.8274 mL 1.6548 mL 4.1370 mL
20 mM 0.1241 mL 0.6205 mL 1.2411 mL 3.1027 mL
25 mM 0.0993 mL 0.4964 mL 0.9929 mL 2.4822 mL
30 mM 0.0827 mL 0.4137 mL 0.8274 mL 2.0685 mL
40 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.5514 mL
50 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2411 mL
60 mM 0.0414 mL 0.2068 mL 0.4137 mL 1.0342 mL
80 mM 0.0310 mL 0.1551 mL 0.3103 mL 0.7757 mL
100 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6205 mL
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Darolutamide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Darolutamide-d42484757-20-0ODM-201-d4 BAY-1841788-d4Androgen ReceptorIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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