2. Oligonucleotides
  3. Polymers

Polymers

The utility of polymers to function as intracellular delivery systems for nucleic acids has been studied for several decades. For instance, cationic polymers are able to condense nucleic acids into polyplexes via electrostatic interactions, enhancing cellular uptake and endosome escape. Notably, the physiochemical properties of polymers (charge, degradability and molecular weight) can be carefully adjusted through bottom-up chemical synthesis. Up to now, cyclodextrin polymer (CDP)-based nanoparticles have entered clinical trials for siRNA delivery.

Polymers (61):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112735
    Hexadimethrine bromide 28728-55-4 99.69%
    Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer.
    Hexadimethrine bromide
  • HY-B2247
    PLGA (50:50) 34346-01-5 99.41%
    PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications.
    PLGA (50:50)
  • HY-B0633A
    Hyaluronic acid 9004-61-9
    Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM). Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer.
    Hyaluronic acid
  • HY-B2247A
    PLGA (75:25) 34346-01-5 99.54%
    PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides.
    PLGA (75:25)
  • HY-135969
    Glycol chitosan 123938-86-3
    Glycol chitosan is a chitosan derivative with ethylene glycol branches. Glycol chitosan enhances membrane permeability and leadkage in Glycine max Harosoy 63W cells. Glycol chitosan is biocompatible and biodegradable. Glycol chitosan inhibits E. coli, S. aureus and S. enteritidis growths with MIC values of 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively.
    Glycol chitosan
  • HY-112624B
    Dextran T70 (MW 70,000) 9004-54-0
    Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.
    Dextran T70 (MW 70,000)
  • HY-D1005H
    Poloxamer 188 (F68) 9003-11-6
    Poloxamer 188 is a nonionic linear copolymer with surfactant properties. Poloxamer 188 exhibits anti-thrombotic, anti-inflammatory, and cytoprotective activities in various tissue injury models.
    Poloxamer 188 (F68)
  • HY-148033
    Trimethyl chitosan 52349-26-5
    Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles.
    Trimethyl chitosan
  • HY-Y0850E
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) 9002-89-5
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients.
    Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)
  • HY-126437A
    Poly-L-lysine hydrochloride 26124-78-7
    Poly-L-lysine hydrochloride is a nonspecific attachment factor for cells useful in promoting cell adhesion to solid substrates by enhancing electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Poly-L-lysine hydrochloride is a strong-attraction regulator that promotes liquid-liquid phase separation (LLPS) at low concentrations but suppresses LLPS at high concentrations. Antibacterial cationic peptide..
    Poly-L-lysine hydrochloride
  • HY-W243303A
    Poly(acrylic acid) (MW 2000) 9003-01-4
    Poly(acrylic acid) (MW 2000) is a polyacrylic acid with a molecular weight of 2000. Poly(acrylic acid) (MW 2000) is an anionic polymer. Poly(acrylic acid) (MW 2000) can be as a corrosion-mitigating and surface-stabilizing agent.
    Poly(acrylic acid) (MW 2000)
  • HY-W243303E
    Poly(acrylic acid) (MW 450000) 9003-01-4
    Poly(acrylic acid) (MW 450000) is a polyacrylic acid with a molecular weight of 450000. Poly(acrylic acid) (MW 450000) is an anionic polymer. Poly(acrylic acid) (MW 450000) can be as a corrosion-mitigating and surface-stabilizing agent.
    Poly(acrylic acid) (MW 450000)
  • HY-126437
    Poly-L-lysine hydrobromide (MW 30000-70000) 25988-63-0
    Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material.
    Poly-L-lysine hydrobromide (MW 30000-70000)
  • HY-Y0850J
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) 9002-89-5
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 130000-23000 and hydrolytic properties. Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate and polyvinyl alcohol is obtained. A degree of hydrolysis of 87-89% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipient. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A).
    Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed)
  • HY-W591424
    m-PEG-NHS ester (MW 2000) 92451-01-9 ≥98.0%
    m-PEG-NHS ester (mPEG-SC) is a first-generation PEG reagent. m-PEG-NHS ester (MW 2000) can be used to modify active molecules and improve their antigenicity, immunogenicity, and help prepare injection preparations. The modification of serine protease lumbrokinase (LK) by m-PEG-NHS ester does not affect its strong fibrinolytic and thrombolytic activities, and has good application prospects.
    m-PEG-NHS ester (MW 2000)
  • HY-145396
    PLGA-PEG-NH2 ≥98.0%
    PLGA-PEG-NH2 is a material to synthesis nanomicelles. PLGA-PEG-NH2 nanomicelle is an efficient delivery system of Irinotecan for targeted colorectal cancer and hepatocellular carcinoma.
    PLGA-PEG-NH2
  • HY-Y0850H
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed) 9002-89-5 99.5%
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed) also known as PVA, is a vinyl water-soluble polymer that can be used as a non-ionic surfactant. It can also be used as a biodegradable polymer and can be used in adhesives, coatings, textiles, ceramics and cosmetics.
    Polyvinyl alcohol (Mw 89000-98000, 99+% hydrolyzed)
  • HY-W591476
    m-PEG-thiol (MW 1000) 134874-49-0 98.66%
    m-PEG-thiol (MW 1000) is a surface modifier that can modify DNA thiolation and is used in the synthesis of gold nanorods (AuNR). m-PEG-thiol (MW 1000) can load thiolated DNA onto AuNR, form a covalent bond with the surface of gold nanoparticles through the thiol group, and stabilize the nanoparticles by the steric hindrance effect of the polyethylene glycol chain, preventing aggregation and enhancing its biocompatibility. m-PEG-thiol (MW 1000) can also provide a platform for the subsequent coupling of biomolecules (such as DNA, antibodies) by replacing surfactants (such as CTAB) on the surface of nanoparticles, thereby exerting its activity in promoting the functionalization of nanomaterials.
    m-PEG-thiol (MW 1000)
  • HY-Y0850K
    Polyvinyl alcohol (Mw 31000-50000, 98-99% hydrolyzed) 9002-89-5 98.5%
    Polyvinyl alcohol (Mw 31000-50000, 98-99% hydrolyzed), also known as PVA, is a vinyl water-soluble polymer that can be used as a non-ionic surfactant. It can also be used as a biodegradable polymer and can be used in adhesives, coatings, textiles, ceramics and cosmetics. Polyvinyl alcohol can be used in tissue engineering by electrospinning. Polyvinyl alcohol can achieve high cellular density, infiltration, and uniform distribution, facilitating functional connections between cells. Polyvinyl alcohol can improve cell vitality through in vitro cultivation. Polyvinyl alcohol demonstrates promising inhibition of ostersarcoma cancer cells with Doxorubicin (HY-15142A).
    Polyvinyl alcohol (Mw 31000-50000, 98-99% hydrolyzed)
  • HY-158089
    PLGA-COOH (MW 80000) (LA/GA 50:50)
    PLGA-COOH (MW 80000) (LA/GA 50:50) is a copolymer, which consist of lactic acid (LA)-glycolic acid (GA) with a molar ratio of 50:50, and a carboxyl terminal groups. PLGA-COOH (MW 80000) (LA/GA 50:50) is utilized in drug delivery system for its biocompatibility and biodegradability.
    PLGA-COOH (MW 80000) (LA/GA 50:50)