2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. SK2187

SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088)).

For research use only. We do not sell to patients.

SK2187

SK2187 Chemical Structure

CAS No. : 3038446-91-9

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Based on 1 publication(s) in Google Scholar

SK2187 Related Antibodies

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Description

SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088))[1].

In Vitro

SK2187 (10-1000 nM, 24 h) induces potent dose-dependent AURKA degradation with a DC50 of about 10 nM and Dmax of 85%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SK2187 Related Antibodies
Molecular Weight

950.43

Formula

C45H49ClFN7O11S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 95.81%

COA (245 KB) HNMR (154 KB) RP-HPLC (165 KB) LCMS (108 KB)

Handling Instructions (2659 KB)
References
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SK2187 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK21873038446-91-9JB301SK 2187SK-2187JB 301JB-301PROTACsAurora KinaseAURKANeuroblastomaPROTACMYCNTargeted protein degradationInhibitorinhibitorinhibit

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