2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs Aurora Kinase
  4. SK2187

SK2187 is a selective AURKA PROTACdegrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088)).

For research use only. We do not sell to patients.

SK2187 Chemical Structure

SK2187 Chemical Structure

CAS No. : 3038446-91-9

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SK2187 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Aurora Kinase Aurora A Aurora B Aurora C

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Description

SK2187 is a selective AURKA PROTACdegrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088))[1].

In Vitro

SK2187 (10-1000 nM, 24 h) induces potent dose-dependent AURKA degradation with a DC50 of about 10 nM and Dmax of 85%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SK2187 Related Antibodies
Molecular Weight

950.43

Formula

C45H49ClFN7O11S
CAS No.
Appearance

Solid

SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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SK2187 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK21873038446-91-9JB301SK 2187SK-2187JB 301JB-301PROTACsAurora KinaseAURKANeuroblastomaPROTACMYCNTargeted protein degradationInhibitorinhibitorinhibit

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HY-171768
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