Uridine diphosphate glucuronic acid-¹³C,¹⁵N₂  (Synonyms: UDP-α-D-glucuronic acid-¹³C,¹⁵N₂)

Uridine diphosphate glucuronic acid-¹³C,¹⁵N₂ (UDP-α-D-glucuronic acid-¹³C,¹⁵N₂) is the ¹³C- and ¹⁵N-labeled Uridine diphosphate glucuronic acid (HY-125954). Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

583.26

C₁₄¹³CH₂₂¹⁵N₂O₁₈P₂

2616-64-0

O=C(C=C[15N]1[C@@H]2O[C@@H]([C@H]([C@H]2O)O)COP(O)(OP(O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)(O)=O)=O)[15NH][13C]1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Annika J E Borg, et al. Mechanistic characterization of UDP-glucuronic acid 4-epimerase. FEBS J. 2021 Feb;288(4):1163-1178.  [Content Brief]

  [2]. DUTTON GJ. Uridine diphosphate glucuronic acid as glucuronyl donor in the synthesis of ester, aliphatic and steroid glucuronides. Biochem J. 1956 Dec;64(4):693-701.  [Content Brief]