2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Melanotan I

Melanotan I  (Synonyms: MT-I; [Nle4,D-Phe7]-α-MSH)

Cat. No.: HY-N2466 Purity: 99.09%
COA
SDS
Handling Instructions Technical Support

Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Melanotan I

Melanotan I Chemical Structure

CAS No. : 75921-69-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Melanotan I:

Melanotan I Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Melanotan I

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MC1R MC3R MC2R MC4R MC5R

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction[1][2][3][4].

IC50 & Target

MC1R

 

In Vitro

Melanotan I (1 μM, 72 h) does not alter or slightly inhibit the formation of tumor colonies, and inhibits melanoma cell proliferation in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Melanotan I Related Antibodies
In Vivo

Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) has no acute toxic effect in rodents[2].
Melanotan I (2/10 mg/kg, s.c.) does not increase tumor incidence of human melanoma in SCID (immunodeficient) mice, nor does it lead to malignant transformation of tumors, and does not exhibit cancer-promoting effects. [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats[2]
Dosage: 0.6 mg/kg/day for 30 days
Administration: s.c.
Result: Well tolerated with no change in lethality, no effect on weight gain, no serum chemistry changes, except for a slight increase (30 %) in lactic dehydrogenase levels.
Molecular Weight

1646.85

Formula

C78H111N21O19
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Ser-Tyr-Ser-{Nle}-Glu-His-{d-Phe}-Arg-Trp-Gly-Lys-Pro-Val-NH2
Sequence Shortening

Ac-SYS-{Nle}-EH-{d-Phe}-RWGKPV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (60.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (30.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6072 mL 3.0361 mL 6.0722 mL
5 mM 0.1214 mL 0.6072 mL 1.2144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (1.52 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (1.52 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (60.72 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.09%

SDS (393 KB)

COA (246 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.6072 mL 3.0361 mL 6.0722 mL 15.1805 mL
5 mM 0.1214 mL 0.6072 mL 1.2144 mL 3.0361 mL
10 mM 0.0607 mL 0.3036 mL 0.6072 mL 1.5180 mL
15 mM 0.0405 mL 0.2024 mL 0.4048 mL 1.0120 mL
20 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.7590 mL
25 mM 0.0243 mL 0.1214 mL 0.2429 mL 0.6072 mL
30 mM 0.0202 mL 0.1012 mL 0.2024 mL 0.5060 mL
DMSO 40 mM 0.0152 mL 0.0759 mL 0.1518 mL 0.3795 mL
50 mM 0.0121 mL 0.0607 mL 0.1214 mL 0.3036 mL
60 mM 0.0101 mL 0.0506 mL 0.1012 mL 0.2530 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Melanotan I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melanotan I75921-69-6MT-I [Nle4,D-Phe7]-α-MSHMelanocortin ReceptorMC Receptorsub cutaneous injectionhuman melanocytesmelanotropic peptideMelanotanskin cancersα-MSHMC1Rmelanocortin receptorInhibitorinhibitorinhibit

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