Metabotropic glutamate receptor 5 Antibody (YA4007)

Metabotropic glutamate receptor 5 Antibody (YA4007) is a mouse-derived and non-conjugated IgG1 antibody, targeting to GRM5. It can be applicated for IHC-P, ICC/IF, ELISA assays, in the background of human.

The GRM5 Protein functions as a G-protein coupled receptor for glutamate, undergoing a conformational change upon ligand binding that initiates signaling through guanine nucleotide-binding proteins (G proteins), ultimately modulating downstream effectors. This signaling cascade activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Integral to the regulation of synaptic plasticity and modulation of neural network activity, GRM5 plays a crucial role in shaping the dynamic responses of the central nervous system. The interaction of the PPXXF motif with HOMER1, HOMER2, and HOMER3 highlights its involvement in intracellular signaling events. Additionally, GRM5 interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3, TAMALIN, and NCDN, with isoform 2 specifically interacting with NECAB2. Further interaction occurs with CAMK2A, emphasizing the intricate network through which GRM5 contributes to the regulation of neural function.

P41594

Predicted band size: 132 kDa; Observed band size: 132 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IHC: 1/200-1/1000; IF: 1/200-1/1000; ELISA: 1/10000

IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human GRM5 (AA: extra 458-580) expressed in E. Coli.