2. Antibody-drug Conjugate/ADC Related
  3. ADC Payload
  4. Dap-NE

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162).

For research use only. We do not sell to patients.

Dap-NE

Dap-NE Chemical Structure

CAS No. : 160800-82-8

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Other Forms of Dap-NE:

Dap-NE Related Antibodies

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162)[1].

Molecular Weight

320.43

Formula

C18H28N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@H](C)[C@@H](OC)[C@H]2NCCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (312.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1208 mL 15.6040 mL 31.2081 mL
5 mM 0.6242 mL 3.1208 mL 6.2416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1208 mL 15.6040 mL 31.2081 mL 78.0202 mL
5 mM 0.6242 mL 3.1208 mL 6.2416 mL 15.6040 mL
10 mM 0.3121 mL 1.5604 mL 3.1208 mL 7.8020 mL
15 mM 0.2081 mL 1.0403 mL 2.0805 mL 5.2013 mL
20 mM 0.1560 mL 0.7802 mL 1.5604 mL 3.9010 mL
25 mM 0.1248 mL 0.6242 mL 1.2483 mL 3.1208 mL
30 mM 0.1040 mL 0.5201 mL 1.0403 mL 2.6007 mL
40 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9505 mL
50 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5604 mL
60 mM 0.0520 mL 0.2601 mL 0.5201 mL 1.3003 mL
80 mM 0.0390 mL 0.1951 mL 0.3901 mL 0.9753 mL
100 mM 0.0312 mL 0.1560 mL 0.3121 mL 0.7802 mL
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Dap-NE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dap-NE160800-82-8ADC PayloadADC CytotoxinInhibitorinhibitorinhibit

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