Varicella zoster virus (HEK293, His)

Glycoprotein E/gE proteins bind to the host cell entry receptor IDE. Varicella zoster virus (HEK293, His) is the recombinant virus-derived Varicella zoster virus (HEK293, His) protein, expressed by HEK293, with C-His labeled tag.

Envelope glycoprotein E (gE) functions as a key player in the viral life cycle by binding to the potential host cell entry receptor IDE. Particularly crucial in epithelial cells, the gE/gI heterodimer is essential for the efficient cell-to-cell spread of the virus, facilitating the sorting of nascent virions to cell junctions. Once positioned at these junctions, rapid virus dissemination to adjacent cells occurs through interactions with cellular receptors that accumulate at these sites. Additionally, gE/gI is implicated in basolateral spread in polarized cells. In neuronal cells, the gE/gI heterodimer plays a vital role in the anterograde spread of the infection throughout the host nervous system. Teaming up with US9, this heterodimer is involved in the sorting and transport of viral structural components toward axon tips, contributing to the orchestrated progression of the infection.

Virus

HEK293

C-His

Q9J3M8-1 (S31-A546)

/

Partial

Approximately 54-69 kDa,based on SDS-PAGE under non-reduced conditions,due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.