Ritonavir-¹³C₃ (Synonyms: ABT 538-¹³C₃; RTV-¹³C₃)

Cat. No.: HY-W653853: Data Sheet Handling Instructions
FAQs
Technical Support

Ritonavir-¹³C₃ is ¹³C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL^pro inhibitor with an IC₅₀ of 1.61 μM.

For research use only. We do not sell to patients.

Ritonavir-<sup>13</sup>C<sub>3</sub> Chemical Structure

Ritonavir-¹³C₃ Chemical Structure

CAS No. : 1217673-23-8

Size	Price	Stock	Quantity
500 μg		In-stock	Estimated Time of Arrival: December 31

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Ritonavir-¹³C₃:

Ritonavir In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

View All Isoforms

HIV HIV-1 HIV-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

723.92

Formula

C₃₄¹³C₃H₄₈N₆O₅S₂

CAS No.

1217673-23-8

Unlabeled CAS

155213-67-5

SMILES

CN(C(N[C@@H](C(C)C)C(N[C@H](C[C@@H]([C@@H](NC(O[13CH2][13C]1=[13CH]N=CS1)=O)CC2=CC=CC=C2)O)CC3=CC=CC=C3)=O)=O)CC4=CSC(C(C)C)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (34.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3814 mL	6.9068 mL	13.8137 mL
5 mM	0.2763 mL	1.3814 mL	2.7627 mL
10 mM	0.1381 mL	0.6907 mL	1.3814 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27(8):902-8. [Content Brief]

[3]. Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44(2):190-4. [Content Brief]

[4]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212. [Content Brief]

[5]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9. [Content Brief]

[6]. Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57(10):1147-52. [Content Brief]

[7]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3814 mL	6.9068 mL	13.8137 mL	34.5342 mL
	5 mM	0.2763 mL	1.3814 mL	2.7627 mL	6.9068 mL
	10 mM	0.1381 mL	0.6907 mL	1.3814 mL	3.4534 mL
	15 mM	0.0921 mL	0.4605 mL	0.9209 mL	2.3023 mL
	20 mM	0.0691 mL	0.3453 mL	0.6907 mL	1.7267 mL
	25 mM	0.0553 mL	0.2763 mL	0.5525 mL	1.3814 mL
	30 mM	0.0460 mL	0.2302 mL	0.4605 mL	1.1511 mL

Ritonavir-¹³C₃ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritonavir-¹³C₃1217673-23-8ABT 538-¹³C₃RTV-¹³C₃HIVHIV ProteaseApoptosisIsotope-Labeled CompoundsSARS-CoVHuman immunodeficiency virusSARS coronavirusInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Ritonavir-13C3 (Synonyms: ABT 538-13C3; RTV-13C3)

Other Forms of Ritonavir-13C3:

Ritonavir-13C3 Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All HIV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ritonavir-13C3 Related Classifications