2. PROTAC Immunology/Inflammation
  3. PROTACs BCL6
  4. PROTAC BCL6 Degrader-2

PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC50s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306)).

For research use only. We do not sell to patients.

PROTAC BCL6 Degrader-2

PROTAC BCL6 Degrader-2 Chemical Structure

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PROTAC BCL6 Degrader-2 Related Antibodies

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Description

PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC50s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306))[1].

IC50 & Target

DC50: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells (BCL6)[1]
Molecular Weight

922.43

Formula

C46H52ClN11O8
SMILES

O=C1N(C(C2=CC(N3CCN(CC3)CC4CCN(CC4)C(C5CCN(C6=NC(NC7=CC(C=C8OCC(NC)=O)=C(C=C7)N(C)C8=O)=C(C=N6)Cl)CC5)=O)=CC=C21)=O)C9CCC(NC9=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BCL6 Degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BCL6 Degrader-2PROTACsBCL6B-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51OCI-LY1HEK293TDLBCLanticancerInhibitorinhibitorinhibit

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PROTAC BCL6 Degrader-2
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