2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mc-Pro-PAB-MMAE

Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

Mc-Pro-PAB-MMAE Chemical Structure

Mc-Pro-PAB-MMAE Chemical Structure

CAS No. : 2766450-03-5

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Based on 1 publication(s) in Google Scholar

Mc-Pro-PAB-MMAE Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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Description

Mc-Pro-PAB-MMAE is a Drug-Linker Conjugate for ADC. Mc-Pro-PAB-MMAE consists of Monomethyl auristatin E (HY-15162) and a linker. Mc-Pro-PAB-MMAE can be used for synthesis of ADCs[1][2].

Molecular Weight

1214.49

Formula

C64H95N9O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H]4N(CCC4)C(CNC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (82.34 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8234 mL 4.1170 mL 8.2339 mL
5 mM 0.1647 mL 0.8234 mL 1.6468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8234 mL 4.1170 mL 8.2339 mL 20.5848 mL
5 mM 0.1647 mL 0.8234 mL 1.6468 mL 4.1170 mL
10 mM 0.0823 mL 0.4117 mL 0.8234 mL 2.0585 mL
15 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
20 mM 0.0412 mL 0.2058 mL 0.4117 mL 1.0292 mL
25 mM 0.0329 mL 0.1647 mL 0.3294 mL 0.8234 mL
30 mM 0.0274 mL 0.1372 mL 0.2745 mL 0.6862 mL
40 mM 0.0206 mL 0.1029 mL 0.2058 mL 0.5146 mL
50 mM 0.0165 mL 0.0823 mL 0.1647 mL 0.4117 mL
60 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.3431 mL
80 mM 0.0103 mL 0.0515 mL 0.1029 mL 0.2573 mL
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Mc-Pro-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mc-Pro-PAB-MMAE2766450-03-5Drug-Linker Conjugates for ADCAntibody Drug Conjugates (ADCs)Inhibitorinhibitorinhibit

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