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  3. Biochemical Assay Reagents MDM-2/p53 Caspase
  4. N,N'-Methylenebisacrylamide

N,N'-Methylenebisacrylamide  (Synonyms: Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide)

Cat. No.: HY-D0848 Purity: 99.66%
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COA
Handling Instructions Technical Support

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel.

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N,N'-Methylenebisacrylamide Chemical Structure

N,N'-Methylenebisacrylamide Chemical Structure

CAS No. : 110-26-9

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Based on 1 publication(s) in Google Scholar

N,N'-Methylenebisacrylamide Related Antibodies

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Description

N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel[1][2][3][4][5][6][7].

IC50 & Target[1][2][3][4][5][6][7]

Caspase-3

 

In Vitro

N,N'-Methylenebisacrylamide (10 μM; 24-48 h) promotes proliferation of HepG2 and Huh-7 hepatic cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N,N'-Methylenebisacrylamide Related Antibodies
In Vivo

N,N'-Methylenebisacrylamide (3 mg/kg; p.o.; daily; 4 weeks) induces liver damage in male Swiss albino mice, increasing hepatic expression of CYP2E1, P53, cleaved caspase-3, and COL1A1[1].
N,N'-Methylenebisacrylamide (30 mg/kg; p.o.; gestational days 6 to 17) reduces mean fetal body weight and increases the proportion of anatomical variations in Swiss mice[2].
N,N'-Methylenebisacrylamide (3 mg/kg; p.o.; daily; 4 weeks) causes severe histopathological changes, fibrosis, and glycogen depletion in testicular tissue in male Swiss albino mice[4].
N,N'-Methylenebisacrylamide (3 mg/kg; p.o.; daily; 4 weeks) induces DNA destruction in the testis of adult rats[5].
N,N'-Methylenebisacrylamide (50-200 mg/kg; p.o.; single) causes dose-dependent changes in sperm abnormality rate and sperm count in male ddY strain mice[6].
N,N'-Methylenebisacrylamide (12.5-200 mg/kg; p.o.; twice a week; 3-12 weeks) reduces the body weights, and the numbers of erythrocytes, leucocytes, platelets, reticulocytes, and bone marrow cells in the blood of both mice and rats, with more significant effects in mice[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice (Mus musculus), weighing 25-30 g, testis damage model induced by N,N'-Methylenebisacrylamide[4]
Dosage: 3 mg/kg
Administration: Oral gavage (p.o.), daily, 4 weeks
Result: Induced an increase in Caspase-3 expression in the testis.
Reduced the levels of albumin, IgG, and antitrypsin.
Altered blood protein fractions.
Increased the number of white blood cells and neutrophils.
Decreased the levels of lymphocytes, red blood cells, and hemoglobin.
Molecular Weight

154.17

Formula

C7H10N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CC(NCNC(C=C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (162.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4863 mL 32.4317 mL 64.8635 mL
5 mM 1.2973 mL 6.4863 mL 12.9727 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

SDS (644 KB)

COA (244 KB) HNMR (121 KB) GC (197 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4863 mL 32.4317 mL 64.8635 mL 162.1587 mL
5 mM 1.2973 mL 6.4863 mL 12.9727 mL 32.4317 mL
10 mM 0.6486 mL 3.2432 mL 6.4863 mL 16.2159 mL
15 mM 0.4324 mL 2.1621 mL 4.3242 mL 10.8106 mL
20 mM 0.3243 mL 1.6216 mL 3.2432 mL 8.1079 mL
25 mM 0.2595 mL 1.2973 mL 2.5945 mL 6.4863 mL
30 mM 0.2162 mL 1.0811 mL 2.1621 mL 5.4053 mL
40 mM 0.1622 mL 0.8108 mL 1.6216 mL 4.0540 mL
50 mM 0.1297 mL 0.6486 mL 1.2973 mL 3.2432 mL
60 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7026 mL
80 mM 0.0811 mL 0.4054 mL 0.8108 mL 2.0270 mL
100 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6216 mL
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N,N'-Methylenebisacrylamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N'-Methylenebisacrylamide110-26-9Bisacrylamide MBA Methylenebisacrylamide N,N-MethylenebisacrylamideBiochemical Assay ReagentsMDM-2/p53Caspasebiochemical assayreagentInhibitorinhibitorinhibit

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