2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. ATM/ATR STAT CDK Hedgehog
  4. Garcinone C (Standard)

Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.

For research use only. We do not sell to patients.

Garcinone C (Standard) Chemical Structure

Garcinone C (Standard) Chemical Structure

CAS No. : 76996-27-5

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Description
Molecular Weight

414.45

Formula

C23H26O7
CAS No.
SMILES

CC(C)(O)CCC1=C(O)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Structure Classification
Initial Source
Storage

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Garcinone C (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Garcinone C (Standard)76996-27-5ATM/ATRSTATCDKHedgehogAtaxia telangiectasia mutatedATM and RAD3 relatedCyclin dependent kinaseInhibitorinhibitorinhibit

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