2. Cell Cycle/DNA Damage Cytoskeleton Autophagy Apoptosis
  3. Microtubule/Tubulin Autophagy Apoptosis
  4. ABT-751 (Standard)

ABT-751 (Standard) is the analytical standard of ABT-751. This product is intended for research and analytical applications. ABT-751 (E7010) is a novel, highly orally bioavailable sulfonamides antimitotic compound and tubulin binder. It prevents tubulin aggregation by binding to the colchicine site on β-tubulin, leading to cell cycle arrest in G2/M phase and inducing apoptosis, thus effectively preventing cell division. ABT-751 induces autophagy by inhibiting the AKT/MTOR signaling pathway. ABT-751 showed significant inhibition against various types of cancer cells, including lung, gastric, colon, and breast cancer.

For research use only. We do not sell to patients.

ABT-751 (Standard)

ABT-751 (Standard) Chemical Structure

CAS No. : 141430-65-1

Size Price Stock Quantity
5 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
10 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
25 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
200 mg   Get quote  
500 mg   Get quote  
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Information
Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

371.41

Formula

C18H17N3O4S
CAS No.
SMILES

COC1=CC=C(C=C1)S(=O)(NC2=C(N=CC=C2)NC3=CC=C(C=C3)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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ABT-751 (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-751 (Standard)141430-65-1Microtubule/TubulinAutophagyApoptosisAntimicrotubule agentβ3‐Tubulinprostate NSCLCbreast apoptosisautophagyInhibitorinhibitorinhibit

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