2. Others Metabolic Enzyme/Protease
  3. Endogenous Metabolite Isotope-Labeled Compounds
  4. Cyclic GMP-13C,15N2

Cyclic GMP-13C,15N2  (Synonyms: Guanosine 3',5'-cyclic-13C,15N2 monophosphate)

Cat. No.: HY-W654000
Handling Instructions Technical Support

Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP (HY-113469). Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.

For research use only. We do not sell to patients.

Cyclic GMP-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>

Cyclic GMP-13C,15N2 Chemical Structure

Size Price Stock Quantity
500 μg In-stock

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclic GMP-13C,15N2:

Cyclic GMP-13C,15N2 Related Antibodies

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Description

Cyclic GMP-13C,15N2 is 13C and 15N labeled Cyclic GMP (HY-113469). Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic GMP-13C,15N2 Related Antibodies
Molecular Weight

348.18

Formula

C913CH12N315N2O7P
Unlabeled CAS
SMILES

O=P1(OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=[13C]([15NH2])[15NH]C4=O)O)O1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 5.83 mg/mL (16.74 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8721 mL 14.3604 mL 28.7208 mL
5 mM 0.5744 mL 2.8721 mL 5.7442 mL
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.8721 mL 14.3604 mL 28.7208 mL 71.8019 mL
5 mM 0.5744 mL 2.8721 mL 5.7442 mL 14.3604 mL
10 mM 0.2872 mL 1.4360 mL 2.8721 mL 7.1802 mL
15 mM 0.1915 mL 0.9574 mL 1.9147 mL 4.7868 mL
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Cyclic GMP-13C,15N2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic GMP-13C,15N2Guanosine 3',5'-cyclic-13C,15N2 monophosphateEndogenous MetaboliteIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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