2. PROTAC
  3. PROTACs
  4. DDD2

DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 consists of the warhead TH10184 connected to the VHL recruiting ligand, VH032, through a saturated aliphatic eight carbon linker. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma. (Structure Note: Blue: NUDT5 inhibitor (HY-176262); Pink: E3 (HY-125845); Black: linker (HY-W001958))

For research use only. We do not sell to patients.

DDD2 Chemical Structure

DDD2 Chemical Structure

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DDD2 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 consists of the warhead TH10184 connected to the VHL recruiting ligand, VH032, through a saturated aliphatic eight carbon linker. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma[1]. (Structure Note: Blue: NUDT5 inhibitor (HY-176262); Pink: E3 (HY-125845); Black: linker (HY-W001958))

In Vitro

DDD2 (2 µM, 24 h) induces robust NUDT5 degradation in U-2 OS cells[1].

DDD2 (0.01-10 µM, 4-96 h) induces concentration- and time-dependent degradation of endogenous NUDT5 in CCRF-CEM cells[1].

DDD2 (1 µM, 24 h) degrades NUDT5 depending on VHL (HY-P76124) not CRBN (HY-P702820) in U-2 OS cells[1].

DDD2 has good solubility and stability with Kinetic Solubility Mean of 6.25 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DDD2 Related Antibodies

Western Blot Analysis[1]

Cell Line: U-2 OS cells
Concentration: 2 µM
Incubation Time: 24 h, pretreating with Doxorubicin (HY-15142A) (1 µg/mL) to induce GFP1-10
Result: Induced robust NUDT5 degradation.

Western Blot Analysis[1]

Cell Line: CCRF-CEM cells
Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 µM
Incubation Time: 4, 24, and 96 h
Result: Showed concentration- and time-dependent degradation of endogenous NUDT5 and achieved Dmax at 24 h.
Molecular Weight

1035.22

Formula

C52H66N12O9S
SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CCCCCCC(N2CCN(CC2)C3=NC4=C(C(N(C(N4C)=O)C)=O)N3CC5=NN=C(O5)C6=CC(OC)=C(C=C6)C)=O)=O)=O)NCC(C=C7)=CC=C7C(SC=N8)=C8C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DDD2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDD2DDD 2DDD-2PROTACsTargeted protein degradation (TPD)Proteolysis targeting chimeras (PROTACs)Ubiquitin-proteasome system (UPS)Breast cancerInhibitorinhibitorinhibit

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