2. Metabolic Enzyme/Protease Anti-infection GPCR/G Protein
  3. Hydroxycarboxylic Acid Receptor (HCAR) Bacterial Endogenous Metabolite
  4. Lactic acid potassium

Lactic acid potassium  (Synonyms: DL-Lactic acid potassium; E-270 potassium)

Cat. No.: HY-B2227C Assay: 60.8%
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Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative.

For research use only. We do not sell to patients.

Lactic acid potassium

Lactic acid potassium Chemical Structure

CAS No. : 996-31-6

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Based on 42 publication(s) in Google Scholar

Other Forms of Lactic acid potassium:

Lactic acid potassium Related Antibodies

Top Publications Citing Use of Products

35 Publications Citing Use of MCE Lactic acid potassium

IF
WB
RT-PCR
IP

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553.  [Abstract]

    Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Co-IP detected the effect of lactate on YY1 protein lactylation modification.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193.  [Abstract]

    Lactate sodium (5-15 mM; 24 h) ​​results​​ in increased H4K12la (red) levels in CCSCs compared to the control group.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.  [Abstract]

    Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698.  [Abstract]

    Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.

    Lactic acid potassium purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309.

    The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.

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    Description

    Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative[3].

    IC50 & Target

    Bacterial[2]
    In Vitro

    Lactic acid (20 mM; 24, 48 h) potassium results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation[1].
    Lactic acid (20 mM; 24 h) potassium shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lactic acid potassium Related Antibodies

    Cell Proliferation Assay[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24, 48 h
    Result: Inhibited cell proliferation and migration.

    Western Blot Analysis[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Showed an increase in the protein expression levels of MCT1 and HCAR1

    RT-PCR[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
    In Vivo

    Lactic acid (1.6 g/kg; pH 7.4; subcutaneous; daily from Day 8 to 30 days) potassium shows CD8+ T cell-dependent tumor growth inhibition in MC38 colon cancer model[2].
    Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2]
    Dosage: 1.6 g/kg
    Administration: Subcutaneous; daily from Day 8 to 30 days
    Result: Significantly suppressed tumor growth.
    Clinical Trial
    Molecular Weight

    128.17

    Formula

    C3H5KO3
    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    OC(C([O-])=O)C.[K+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (390.11 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.8021 mL 39.0107 mL 78.0214 mL
    5 mM 1.5604 mL 7.8021 mL 15.6043 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 60.8%

    SDS (393 KB)

    COA (245 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.8021 mL 39.0107 mL 78.0214 mL 195.0534 mL
    5 mM 1.5604 mL 7.8021 mL 15.6043 mL 39.0107 mL
    10 mM 0.7802 mL 3.9011 mL 7.8021 mL 19.5053 mL
    15 mM 0.5201 mL 2.6007 mL 5.2014 mL 13.0036 mL
    20 mM 0.3901 mL 1.9505 mL 3.9011 mL 9.7527 mL
    25 mM 0.3121 mL 1.5604 mL 3.1209 mL 7.8021 mL
    30 mM 0.2601 mL 1.3004 mL 2.6007 mL 6.5018 mL
    40 mM 0.1951 mL 0.9753 mL 1.9505 mL 4.8763 mL
    50 mM 0.1560 mL 0.7802 mL 1.5604 mL 3.9011 mL
    60 mM 0.1300 mL 0.6502 mL 1.3004 mL 3.2509 mL
    80 mM 0.0975 mL 0.4876 mL 0.9753 mL 2.4382 mL
    100 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9505 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Lactic acid potassium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lactic acid996-31-6DL-Lactic acidE-270E270E 270Hydroxycarboxylic Acid Receptor (HCAR)BacterialEndogenous Metabolitehydroxycarboxylic acid receptor 1HCAR1epigeneticlysine residues lactylationglycolysisoxidative phosphorylationoncometaboliteanti-tumorInhibitorinhibitorinhibit

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