Lactic acid sodium (60% w/w in water) (Synonyms: DL-Lactic acid sodium; E-270 sodium)

Name: Lactic acid sodium (60% w/w in water)
Brand: MedChemExpress
SKU: HY-B2227B
Rating: 5.0 (44 reviews)

Cat. No.: HY-B2227B Purity: 98.0%: Data Sheet
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Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative.

For research use only. We do not sell to patients.

CAS No. : 72-17-3

Size	Stock	Quantity
Solvent
200 μL	In-stock	Estimated Time of Arrival: December 31
Solvent
1 mL	In-stock	Estimated Time of Arrival: December 31
Solvent
2 mL	In-stock	Estimated Time of Arrival: December 31
Solvent
5 mL	In-stock	Estimated Time of Arrival: December 31
Solvent
10 mL	In-stock	Estimated Time of Arrival: December 31
50 mL	Get quote
100 mL	Get quote

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Based on 44 publication(s) in Google Scholar

Other Forms of Lactic acid sodium (60% w/w in water):

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L-Lactic acid-¹³C-1 sodium (20% w/w in water) In-stock
L-Lactic acid sodium In-stock
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37 Publications Citing Use of MCE Lactic acid sodium (60% w/w in water)

RT-PCR

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553. [Abstract]; Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]; Co-IP detected the effect of lactate on YY1 protein lactylation modification.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]; Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193. [Abstract]; Lactate sodium (5-15 mM; 24 h) results in increased H4K12la (red) levels in CCSCs compared to the control group.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68. [Abstract]; Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698. [Abstract]; Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.

: Lactic acid sodium (60% w/w in water) purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309.; The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.

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Description

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity^[1]^[2]. Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative^[3].

In Vitro

Lactic acid (20 mM; 24, 48 h) sodium (60% w/w in water) results in a significant decrease in cell proliferation and migration, acting and switching cell metabolism toward oxidative phosphorylation^[1].
Lactic acid (20 mM; 24 h) sodium (60% w/w in water) shows an increase in the protein and mRNA expression levels of MCT1 and HCAR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Uveal melanoma 92.1 cells
Concentration:	20 mM
Incubation Time:	24, 48 h
Result:	Inhibited cell proliferation and migration.

Western Blot Analysis^[1]

Cell Line:	Uveal melanoma 92.1 cells
Concentration:	20 mM
Incubation Time:	24 h
Result:	Showed an increase in the protein expression levels of MCT1 and HCAR1

RT-PCR^[1]

Cell Line:	Uveal melanoma 92.1 cells
Concentration:	20 mM
Incubation Time:	24 h
Result:	Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.

In Vivo

Lactic acid (1.6 g/kg; pH 7.4; subcutaneous; daily from Day 8 to 30 days) sodium (60% w/w in water) shows CD8+ T cell-dependent tumor growth inhibition in MC38 colon cancer model^[2].
Note: The pH of the working solution needs to be adjusted to around 7.4 before administration to animals.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice with MC38 colon cancer cells^[2]
Dosage:	1.6 g/kg
Administration:	Subcutaneous; daily from Day 8 to 30 days
Result:	Significantly suppressed tumor growth.

Clinical Trial

Molecular Weight

112.06

Formula

C₃H₅NaO₃

CAS No.

72-17-3

Appearance

Liquid (Density: 1.33 g/cm³)

Color

Colorless to light yellow

SMILES

[Na].O=C(O)C(O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility

In Vitro:

H₂O : ≥ 150 mg/mL (1338.57 mM)

*"≥" means soluble, but saturation unknown.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

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Data Sheet (278 KB) SDS (393 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24. [Content Brief]

[2]. Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981. [Content Brief]

[3]. Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18(5):566-575. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	8.9238 mL	44.6190 mL	89.2379 mL	223.0948 mL
	5 mM	1.7848 mL	8.9238 mL	17.8476 mL	44.6190 mL
	10 mM	0.8924 mL	4.4619 mL	8.9238 mL	22.3095 mL
	15 mM	0.5949 mL	2.9746 mL	5.9492 mL	14.8730 mL
	20 mM	0.4462 mL	2.2309 mL	4.4619 mL	11.1547 mL
	25 mM	0.3570 mL	1.7848 mL	3.5695 mL	8.9238 mL
	30 mM	0.2975 mL	1.4873 mL	2.9746 mL	7.4365 mL
	40 mM	0.2231 mL	1.1155 mL	2.2309 mL	5.5774 mL
	50 mM	0.1785 mL	0.8924 mL	1.7848 mL	4.4619 mL
	60 mM	0.1487 mL	0.7436 mL	1.4873 mL	3.7182 mL
	80 mM	0.1115 mL	0.5577 mL	1.1155 mL	2.7887 mL
	100 mM	0.0892 mL	0.4462 mL	0.8924 mL	2.2309 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lactic acid sodium (60% w/w in water) (Synonyms: DL-Lactic acid sodium; E-270 sodium)

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Other Forms of Lactic acid sodium (60% w/w in water):

Lactic acid sodium (60% w/w in water) Related Antibodies

37 Publications Citing Use of MCE Lactic acid sodium (60% w/w in water)

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Lactic acid sodium (60% w/w in water) Related Antibodies

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Lactic acid sodium (60% w/w in water) Related Classifications

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