PROTAC sEH degrader-2 

PROTAC sEH degrader-2 is a PROTAC targeting degradation agent for soluble epoxide hydrolase (sEH) with pIC₅₀ values of the catalytic domain of 8.37 (human sEH-H) and 7.12 (mouce sEH-H). PROTAC sEH degrader-2 can be used for the research related to inflammation and neuroinflammation, such as Alzheimer's disease^[1]. (Structure Note: Pink: sEH-H ligand (HY-174225); Blue: E3 ligase Ligand (HY-103597); E3 + linker (HY-141011))

PROTAC sEH degrader-2 (Compound 23) (0-10 μM, 1-24 h) shows high degradation potencies towards hsEH-H in the nanomolar range and the highest D_max (75%) after 18 h^[1].

PROTAC sEH degrader-2 (0.5-50 μM, 72 h) shows no significant toxicity in HepG2 cells^[1].

PROTAC sEH degrader-2 (300 nM) initiates the degradation of sEH in human primary M1 macrophages, primary murine hepatocytes and human isolated lung slices^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1148.14

C₅₄H₅₇F₄N₉O₁₃S

O=C(NCC1=C(C=C(C=C1)NS(=O)(CCCC2=CN(N=N2)CCOCCOCCOCCOCCNC(COC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)=O)C(F)(F)F)C6=CC=C7N(C=CC7=C6)CC8=CC=CC(F)=C8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schönfeld J, et al. Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. J Med Chem. 2025 Jul 10;68(13):13728-13749.  [Content Brief]