Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride

Cat. No.: HY-157566 Purity: 98.57%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated.

For research use only. We do not sell to patients.

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride Chemical Structure

CAS No. : 2520105-60-4

Size	Stock	Quantity
Free Sample (0.1 - 0.2 mg)	Apply Now
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Cereblon

Molecular Weight

498.45

Formula

C₂₃H₃₃Cl₂N₅O₃

CAS No.

2520105-60-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CCNCC5)CC4)C=C3C2)=O)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (50.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0062 mL	10.0311 mL	20.0622 mL
5 mM	0.4012 mL	2.0062 mL	4.0124 mL
10 mM	0.2006 mL	1.0031 mL	2.0062 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.57%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (247 KB) HNMR (139 KB) RP-HPLC (168 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Yi Chen, et al. Mdm2 degrader. WO2023230059A1.2023-11-30.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0062 mL	10.0311 mL	20.0622 mL	50.1555 mL
	5 mM	0.4012 mL	2.0062 mL	4.0124 mL	10.0311 mL
	10 mM	0.2006 mL	1.0031 mL	2.0062 mL	5.0155 mL
	15 mM	0.1337 mL	0.6687 mL	1.3375 mL	3.3437 mL
	20 mM	0.1003 mL	0.5016 mL	1.0031 mL	2.5078 mL
	25 mM	0.0802 mL	0.4012 mL	0.8025 mL	2.0062 mL
	30 mM	0.0669 mL	0.3344 mL	0.6687 mL	1.6718 mL
	40 mM	0.0502 mL	0.2508 mL	0.5016 mL	1.2539 mL
	50 mM	0.0401 mL	0.2006 mL	0.4012 mL	1.0031 mL