Trolox 

Trolox (GMP) is Trolox (HY-101445) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage^[1][2].

Trolox (GMP) has shown to protect mammalian cells from oxidative damage. Trolox (GMP) is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion^[1].
Trolox (GMP) could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or post-treatment of cells with Trolox (GMP) reduced H₂O₂-induced DNA fragmentation to control levels and below. ^[2].
Trolox (GMP) is a hydrophilic analog of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox (GMP) prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

250.29

C₁₄H₁₈O₄

53188-07-1

O=C(C1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mickle DA, et al. Myocardial salvage with trolox and ascorbic acid for an acute evolving infarction. Ann Thorac Surg. 1989 Apr;47(4):553-7.  [Content Brief]

  [2]. Forrest VJ, et al. Oxidative stress-induced apoptosis prevented by Trolox. Free Radic Biol Med. 1994 Jun;16(6):675-84.  [Content Brief]

  [3]. Wu TW, et al. The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol. 1990 Oct;68(10):1189-94.  [Content Brief]