2. Metabolic Enzyme/Protease
  3. N-myristoyltransferase
  4. NMT-IN-8

NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection).

For research use only. We do not sell to patients.

NMT-IN-8 Chemical Structure

NMT-IN-8 Chemical Structure

CAS No. : 2765258-26-0

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NMT-IN-8 Related Antibodies

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Description

NMT-IN-8 (Compound Ex.129) is an orally active and highly selective inhibitor of N-myristoyl transferase (NMT) with an IC50 value of ＜10 nM. NMT-IN-8 binds to the peptide binding pocket of NMT, blocking its catalyzed protein N-myristoylation to interfere with key pathways such as protein trafficking, signal transduction, and viral replication. NMT-IN-8 is promising for research of oncology (e.g., MYC-addicted cancers, B-cell lymphoma) and infectious diseases (e.g., malaria, HIV, rhinovirus infection)[1].

Molecular Weight

468.98

Formula

C23H29ClN8O
CAS No.
SMILES

O=C(C1CN(C2=NC(N3[C@H](CNCC3)C)=NC=C2Cl)C1)NC(C)(C4=CN=C5N4C=CC=C5)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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NMT-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMT-IN-82765258-26-0N-myristoyltransferaseNMTorally activeprotein traffickingsignal transductionand viral replicationInhibitorinhibitorinhibit

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