2. Apoptosis Metabolic Enzyme/Protease Cytoskeleton
  3. Apoptosis Bcl-2 Family Caspase MMP Cadherin
  4. Apoptosis inducer 44

Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer.

For research use only. We do not sell to patients.

Apoptosis inducer 44

Apoptosis inducer 44 Chemical Structure

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Apoptosis inducer 44 Related Antibodies

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Description

Apoptosis inducer 44 is an apoptosis inducer. Apoptosis inducer 44 triggers apoptosis in MDA-MB-231 cells by increasing the levels of Bax and Cyt C, reducing Bcl-2, and initiating caspase-3 cleavage. Apoptosis inducer 44 suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2 and MMP-9 expression and up-regulating E-cadherin protein levels. Apoptosis inducer 44 can be used for the study of breast cancer[1].

IC50 & Target[1]

Caspase 3

 

Bax

 

Bcl-2

 

MMP-2

 

MMP-9

 

In Vitro

Apoptosis inducer 44 (Compound 19) (72 h) shows cytotoxic activity against MDA-MB-231 cells, MCF-7 cells, 4T1 cells and Aml-12 cells, with IC50 values of 4.13, 8.60, 39.95 and 31.60 μM[1].
Apoptosis inducer 44 (10‑40 μM) induces MDA-MB-231 cells apoptosis via the mitochondrial pathway[1].
Apoptosis inducer 44 (5-40 μM) suppresses the invasion and migration of MDA-MB-231 cells by down-regulating MMP-2/MMP-9 expression and up-regulating E-cadherin protein levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 44 Related Antibodies
In Vivo

Apoptosis inducer 44 (Compound 19) (20 mg/kg, for 18 days) significantly suppresses tumor growth in nude mice xenografted with MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

483.61

Formula

C30H36F3NO
SMILES

OC1=CC=C(/C=C/C(C=C)(C)CC/C=C(C)\C)C=C1C(N2CCCCC2)C3=CC(F)=C(F)C(F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptosis inducer 44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 44Apoptosis inducer44Apoptosis inducer-44ApoptosisBcl-2 FamilyCaspaseMMPCadherinMatrix metalloproteinasesAnti-breast cancerMDA-MB-231 cellsMCF-7 cells4T1 cellsAml-12 cellsInhibitorinhibitorinhibit

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