2. Epigenetics PROTAC
  3. Histone Methyltransferase PROTACs WDR5
  4. MS33

MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

MS33

MS33 Chemical Structure

CAS No. : 2407449-11-8

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Based on 1 publication(s) in Google Scholar

MS33 Related Antibodies

Top Publications Citing Use of Products

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].

IC50 & Target[1]

VHL

 

WDR5

120 nM (Kd)

VCB

870 nM (Kd)

In Vitro

MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MS33 Related Antibodies

Western Blot Analysis[1]

Cell Line: MV4;11 cells
Concentration: 0.05, 0.1, 0.5, 1, 5 μM
Incubation Time: 1, 2, 4, 8, 16, 24 hours
Result: Concentration- and time-dependently induced WDR5 degradation.
The DC50 of MS33 was 260 nM, and the maximum degradation of 71%.
Molecular Weight

1208.48

Formula

C64H84F3N11O7S
CAS No.
SMILES

CN(CC1)CCN1C(C(NC(C2=CNC(C=C2C(F)(F)F)=O)=O)=C3)=CC=C3C4=CC(CN5CCN(CCNC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)CC5)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS33 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS332407449-11-8MS 33MS-33Histone MethyltransferasePROTACsWDR5WD repeat protein-5WD40 repeat domain protein 5VCBE3ligaseVHLproteasomeacutemyeloidleukemiaInhibitorinhibitorinhibit

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