Triclosan-¹³C₆

Cat. No.: HY-W653962: Data Sheet
SDS

COA
Handling Instructions
FAQs
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Triclosan-¹³C₆ is ¹³C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

For research use only. We do not sell to patients.

Triclosan-<sup>13</sup>C<sub>6</sub> Chemical Structure

Triclosan-¹³C₆ Chemical Structure

CAS No. : 2726926-25-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of Triclosan-¹³C₆:

Triclosan In-stock

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

295.50

Formula

C₆¹³C₆H₇Cl₃O₂

CAS No.

2726926-25-4

Unlabeled CAS

3380-34-5

Appearance

Solid

Color

White to light brown

SMILES

OC1=CC(Cl)=CC=C1O[13C]2=[13C]([13CH]=[13C]([13CH]=[13CH]2)Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

Methanol : 100 mg/mL (338.41 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (338.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3841 mL	16.9205 mL	33.8409 mL
5 mM	0.6768 mL	3.3841 mL	6.7682 mL
10 mM	0.3384 mL	1.6920 mL	3.3841 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.51%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136. [Content Brief]

[3]. R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4. [Content Brief]

[4]. Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol / DMSO	1 mM	3.3841 mL	16.9205 mL	33.8409 mL	84.6024 mL
	5 mM	0.6768 mL	3.3841 mL	6.7682 mL	16.9205 mL
	10 mM	0.3384 mL	1.6920 mL	3.3841 mL	8.4602 mL
	15 mM	0.2256 mL	1.1280 mL	2.2561 mL	5.6402 mL
	20 mM	0.1692 mL	0.8460 mL	1.6920 mL	4.2301 mL
	25 mM	0.1354 mL	0.6768 mL	1.3536 mL	3.3841 mL
	30 mM	0.1128 mL	0.5640 mL	1.1280 mL	2.8201 mL
	40 mM	0.0846 mL	0.4230 mL	0.8460 mL	2.1151 mL
	50 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6920 mL
	60 mM	0.0564 mL	0.2820 mL	0.5640 mL	1.4100 mL
	80 mM	0.0423 mL	0.2115 mL	0.4230 mL	1.0575 mL
	100 mM	0.0338 mL	0.1692 mL	0.3384 mL	0.8460 mL