Difethialone-d₄  (Synonyms: Baraki-d₄; LM 2219-d₄)

Difethialone-d₄ (Baraki-d₄; LM 2219-d₄) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

543.51

C₃₁H₁₉D₄BrO₂S

2714420-97-8

104653-34-1

O=C1C(C2CC(C3=CC=C(C4=CC=C(Br)C=C4)C=C3)CC5=C2C=CC=C5)=C(O)C6=C([2H])C([2H])=C([2H])C([2H])=C6S1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nahas K, et al. Difethialone (LM-2219): a new anticoagulant rodenticide for use against warfarin-resistant and-susceptible strains of Rattus norvegicus and Mus musculus[C]//Annales de Recherches Veterinaires. 1989, 20(2): 159-164.  [Content Brief]