1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Imidazole-d4

Imidazole-d4  (Synonyms: Glyoxaline-d4; 1,3-Diaza-2,4-cyclopentadiene-d4)

Cat. No.: HY-D0837S Purity: 99.94%
Handling Instructions Technical Support

Imidazole-d4 is the deuterium labeled Imidazole.

For research use only. We do not sell to patients.

Imidazole-d<sub>4</sub> Chemical Structure

Imidazole-d4 Chemical Structure

CAS No. : 6923-01-9

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Description

Imidazole-d4 is the deuterium labeled Imidazole[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

72.10

Formula

C3D4N2

CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]N1C([2H])=NC([2H])=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1386.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.8696 mL 69.3481 mL 138.6963 mL
5 mM 2.7739 mL 13.8696 mL 27.7393 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 13.8696 mL 69.3481 mL 138.6963 mL 346.7406 mL
5 mM 2.7739 mL 13.8696 mL 27.7393 mL 69.3481 mL
10 mM 1.3870 mL 6.9348 mL 13.8696 mL 34.6741 mL
15 mM 0.9246 mL 4.6232 mL 9.2464 mL 23.1160 mL
20 mM 0.6935 mL 3.4674 mL 6.9348 mL 17.3370 mL
25 mM 0.5548 mL 2.7739 mL 5.5479 mL 13.8696 mL
30 mM 0.4623 mL 2.3116 mL 4.6232 mL 11.5580 mL
40 mM 0.3467 mL 1.7337 mL 3.4674 mL 8.6685 mL
50 mM 0.2774 mL 1.3870 mL 2.7739 mL 6.9348 mL
60 mM 0.2312 mL 1.1558 mL 2.3116 mL 5.7790 mL
80 mM 0.1734 mL 0.8669 mL 1.7337 mL 4.3343 mL
100 mM 0.1387 mL 0.6935 mL 1.3870 mL 3.4674 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Imidazole-d4
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HY-D0837S
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