2. PROTAC Epigenetics
  3. Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain
  4. Ad-JQ1

Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256).

For research use only. We do not sell to patients.

Ad-JQ1

Ad-JQ1 Chemical Structure

CAS No. : 2497485-14-8

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Ad-JQ1 Related Antibodies

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Description

Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256)[1].

IC50 & Target[1]

BRD4

 

Molecular Weight

707.32

Formula

C37H47ClN6O4S
CAS No.
SMILES

O=C(NCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)CC5(C[C@@H](C6)C7)C[C@@H]7C[C@@H]6C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ad-JQ1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ad-JQ12497485-14-8Target Protein Ligand-Linker ConjugatesEpigenetic Reader DomainTarget Protein Ligand-Linker ConjugateBRD4β-NF-JQ1Inhibitorinhibitorinhibit

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