2. Others Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Androgen Receptor Thyroid Hormone Receptor Estrogen Receptor/ERR Isotope-Labeled Compounds Cytochrome P450
  4. 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 

Cat. No.: HY-W713284
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2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.

For research use only. We do not sell to patients.

2-Ethylhexyl (E)-3-(4-(methoxy-d<sub>3</sub>)phenyl)acrylate Chemical Structure

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate Chemical Structure

CAS No. : 2734919-82-3

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2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo[1][2][3][4][5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate Related Antibodies
Molecular Weight

293.42

Formula

C18H23D3O3
CAS No.
Unlabeled CAS
SMILES

CCCCC(COC(/C=C/C1=CC=C(C=C1)OC([2H])([2H])[2H])=O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate2734919-82-3Androgen ReceptorThyroid Hormone ReceptorEstrogen Receptor/ERRIsotope-Labeled CompoundsCytochrome P450THRCYPsInhibitorinhibitorinhibit

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