1. Cytoskeleton Immunology/Inflammation
  2. Integrin PD-1/PD-L1
  3. NOTA-IMB-RGD

NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1). NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer).

For research use only. We do not sell to patients.

NOTA-IMB-RGD

NOTA-IMB-RGD Chemical Structure

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Description

NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1). NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer)[1].

Molecular Weight

2659.06

Formula

C118H196N30O37S

SMILES

O=C(NCCCCC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C)C(N1CCC[C@H]1C(N[C@H](CC(N)=O)C(N[C@@H]([C@H](CC)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](CO)C(N[C@@H](C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CO)=O)CS)=O)=O)CC(C)C)=O)NC(CCCCNC(CN2CCN(CCN(CC2)CC(O)=O)CC(O)=O)=O)=O)COCCOCCNC(CCC(NCCCCC3NC([C@H](NC(CNC(C(NC([C@@H](NC3=O)CC4=CC=CC=C4)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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NOTA-IMB-RGD
Cat. No.:
HY-175323
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