2. PROTAC
  3. PROTAC Linkers
  4. Tos-PEG4-t-butyl ester

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM.

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Tos-PEG4-t-butyl ester

Tos-PEG4-t-butyl ester Chemical Structure

CAS No. : 217817-01-1

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Based on 1 publication(s) in Google Scholar

Tos-PEG4-t-butyl ester Related Antibodies

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Description

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

Molecular Weight

432.53

Formula

C20H32O8S
CAS No.
Appearance

Liquid (Density: 1.154±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Tos-PEG4-t-butyl ester Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tos-PEG4-t-butyl ester217817-01-1Tos-PEG4-BocPROTAC LinkersPROTACPEGlinkerBI-3663Inhibitorinhibitorinhibit

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