Anti-TROP-2 Antibody (Pr1E11)

Cat. No.: HY-P990827 Purity: 95.00%: Data Sheet
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Anti-TROP-2 Antibody (Pr1E11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human TROP-2. Anti-TROP-2 Antibody (Pr1E11) reacts with human TROP-2, also known as TACSTD2 (Tumor-associated calcium signal transducer 2). Anti-TROP-2 Antibody (Pr1E11) can be used for the research of cancer, such as BxPC3 and Colo205 tumor.

For research use only. We do not sell to patients.

Anti-TROP-2 Antibody (Pr1E11) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Mouse IgG1 kappa

Species Reactivity

Human

IC₅₀ & Target

TROP-2

In Vitro

Anti-TROP-2 Antibody (Pr1E11) (defucosylated [Fuc(−)] chimeric Pr1E11) (0.1-1,000 ng/mL, 4 h) shows antibody-dependent cellular cytotoxicity (ADCC) activity but not complement-dependent cytotoxicity (CDC) activity in BxPC3 and Colo205 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-TROP-2 Antibody (Pr1E11) (defucosylated [Fuc(−)] chimeric Pr1E11) (200 μg, i.p., twice a week for 4 weeks) shows anti-tumor effect in BxPC3/Colo205 tumor SCID mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BxPC3/Colo205 tumor SCID mice^[1]
Dosage:	200 μg
Administration:	Intraperitoneally injection, twice a week for 4 weeks
Result:	Suppressed tumor growth. Showed the minimum tumor growth inhibition ratio (T/Cmin) with 0.36 and 0.29, respectively.

Gene ID

56753 [NCBI]

Accession

Q8BGV3

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-TROP-2 Antibody (Pr1E11)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

Anti-TROP-2 Antibody (Pr1E11) Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-TROP-2 Antibody (Pr1E11)Transmembrane GlycoproteinTROP-2TACSTD2BxPC3Colo205Inhibitorinhibitorinhibit

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