2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. VH 101-amide-piperidine-Pip-alkyne

VH 101-amide-piperidine-Pip-alkyne is an E3 Ligase Ligand-Linker Conjugates that can be used to synthesize PROTAC degrader. The linker part of VH 101-amide-piperidine-Pip-alkyne is tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and the VHL-type E3 ubiquitinase ligand is VH 101, acid (HY-47070).

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VH 101-amide-piperidine-Pip-alkyne Chemical Structure

VH 101-amide-piperidine-Pip-alkyne Chemical Structure

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VH 101-amide-piperidine-Pip-alkyne Related Antibodies

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Description

VH 101-amide-piperidine-Pip-alkyne is an E3 Ligase Ligand-Linker Conjugates that can be used to synthesize PROTAC degrader. The linker part of VH 101-amide-piperidine-Pip-alkyne is tert-Butyl 4-ethynyl-[1,4'-bipiperidine]-1'-carboxylate (HY-W442074), and the VHL-type E3 ubiquitinase ligand is VH 101, acid (HY-47070)[1].

Molecular Weight

748.95

Formula

C40H53FN6O5S
SMILES

C#CC1CCN(C2CCN(C(C[C@H](NC([C@H]3N(C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)C[C@H](O)C3)=O)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)CC2)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VH 101-amide-piperidine-Pip-alkyne Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 101-amide-piperidine-Pip-alkyneE3 Ligase Ligand-Linker ConjugatesPROTACVHLPCamCRPCInhibitorinhibitorinhibit

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