6-Methoxy-2-naphthoic acid (Synonyms: 6-MNA; Naproxen impurity O)

Cat. No.: HY-B2121 Purity: 99.68%: Data Sheet
COA

SDS
Handling Instructions
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6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E₂. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.

For research use only. We do not sell to patients.

6-Methoxy-2-naphthoic acid Chemical Structure

CAS No. : 2471-70-7

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
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100 g	In-stock	Estimated Time of Arrival: December 31
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Other Forms of 6-Methoxy-2-naphthoic acid:

6-Methoxy-2-naphthoic acid (Standard) Get quote

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

6-Methoxy-2-naphthoic acid (0-100 μM; 0-24 h) inhibits COX-1 and COX-2 with IC₅₀ values of 31.01 μM and 19.84 μM, respectively (in human whole blood)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

202.21

Formula

C₁₂H₁₀O₃

CAS No.

2471-70-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2C=C(OC)C=CC2=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 60 mg/mL (296.72 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9454 mL	24.7268 mL	49.4535 mL
5 mM	0.9891 mL	4.9454 mL	9.8907 mL
10 mM	0.4945 mL	2.4727 mL	4.9454 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (24.73 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (117 KB) RP-HPLC (190 KB)

Handling Instructions (2659 KB)

References

[1]. Cryer B, et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998 May;104(5):413-21. [Content Brief]

[2]. Narayana B, et al. Synthesis of some new 2-(6-methoxy-2-naphthyl)- 5-aryl-1,3,4-oxadiazoles as possible non-steroidal anti-inflammatory and analgesic agents. Arch Pharm (Weinheim). 2005 Aug;338(8):373-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.9454 mL	24.7268 mL	49.4535 mL	123.6338 mL
	5 mM	0.9891 mL	4.9454 mL	9.8907 mL	24.7268 mL
	10 mM	0.4945 mL	2.4727 mL	4.9454 mL	12.3634 mL
	15 mM	0.3297 mL	1.6485 mL	3.2969 mL	8.2423 mL
	20 mM	0.2473 mL	1.2363 mL	2.4727 mL	6.1817 mL
	25 mM	0.1978 mL	0.9891 mL	1.9781 mL	4.9454 mL
	30 mM	0.1648 mL	0.8242 mL	1.6485 mL	4.1211 mL
	40 mM	0.1236 mL	0.6182 mL	1.2363 mL	3.0908 mL
	50 mM	0.0989 mL	0.4945 mL	0.9891 mL	2.4727 mL
	60 mM	0.0824 mL	0.4121 mL	0.8242 mL	2.0606 mL
	80 mM	0.0618 mL	0.3091 mL	0.6182 mL	1.5454 mL
	100 mM	0.0495 mL	0.2473 mL	0.4945 mL	1.2363 mL

6-Methoxy-2-naphthoic acid Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Methoxy-2-naphthoic acid2471-70-76-MNA Naproxen impurity ODrug MetaboliteCOXCyclooxygenasemetaboliteNabumetoneNaproxenInhibitorinhibitorinhibit

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