CD169 Antibody (YA1293)

CD169 Antibody (YA1293) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1293), targeting CD169. CD169 Antibody (YA1293) can be used for WB, FC experiment in human,Mouse background.

CD169 is a macrophage-restricted adhesion molecule that mediates sialic-acid-dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells, and CD8 T-cells. It plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for adaptive immune responses. CD169 also mediates the uptake of various enveloped viruses via sialic acid recognition, inducing the formation of intracellular compartments filled with virions (VCCs), thereby enhancing macrophage-to-T-cell transmission of viruses such as HIV-1 or SARS-CoV-2. It acts as an endocytic receptor mediating clathrin-dependent endocytosis and preferentially binds to alpha-2,3-linked sialic acid (by similarity: binds to SPN/CD43 on T-cells). Additionally, CD169 may play a role in hemopoiesis and inhibits antiviral innate immunity by promoting TBK1 degradation via TYROBP- and TRIM27-mediated ubiquitination. In microbial infections, it facilitates viral cytoplasmic entry into activated dendritic cells by recognizing sialylated gangliosides on viral membranes.

Q9BZZ2

Predicted band size: 183 kDa； Observed band size: 220 kDa

Protein A

Non-conjugated

Unmodified

Cell biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse

WB: 1:2,000;FC: 1/2000

WB, FC

K-562 cell lysate, RAW264.7 cell lysate, THP-1 cells treated with 50ng/mL PMA for 72 hours add 1μg/mL LPS for 24 hours, RAW264.7 cells treated with 1μg/mL LPS for 24 hours.

Liquid

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein within human CD169 aa 1-1,000 / 1,709.