2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Topoisomerase DNA/RNA Synthesis
  4. DNA gyrase/Topo IV-IN-2

DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC50 values of 0.783 μM and 7.136 μM against E. coli DNA gyrase and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs.

For research use only. We do not sell to patients.

DNA gyrase/Topo IV-IN-2

DNA gyrase/Topo IV-IN-2 Chemical Structure

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DNA gyrase/Topo IV-IN-2 Related Antibodies

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Description

DNA gyrase/Topo IV-IN-2 (Compound AK19) is an antibacterial agent with IC50 values of 0.783 μM and 7.136 μM against E. coli DNA gyrase and topoisomerase IV, respectively. DNA gyrase/Topo IV-IN-2 exhibits broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative pathogens. DNA gyrase/Topo IV-IN-2 can inhibit the biofilms of B. subtilis and MRSA, with an MIC of 1.9 μM against both B. subtilis and MRSA. DNA gyrase/Topo IV-IN-2 can be used in research related to anti-drug-resistant bacterial drugs[1].

Molecular Weight

463.48

Formula

C25H25N3O6
SMILES

O=CC1=CC=C(OC)C(OCC2=CN(CCCCCOC3=CC(O4)=C(C=C3)C=CC4=O)N=N2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DNA gyrase/Topo IV-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNA gyrase/Topo IV-IN-2BacterialTopoisomeraseDNA/RNA SynthesisE. coliGram-positive and Gram-negative pathogensB. subtilisMRSAInhibitorinhibitorinhibit

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