2. Others Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Potassium Channel iGluR Sodium Channel GABA Receptor Carbonic Anhydrase Calcium Channel
  4. Topiramate-13C6

Topiramate-13C6  (Synonyms: McN 4853-13C6; RWJ 17021-13C6)

Cat. No.: HY-B0122S
Handling Instructions Technical Support

Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

For research use only. We do not sell to patients.

Topiramate-<sup>13</sup>C<sub>6</sub> Chemical Structure

Topiramate-13C6 Chemical Structure

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Other Forms of Topiramate-13C6:

Topiramate-13C6 Related Antibodies

Top Publications Citing Use of Products

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AMPA Receptor NMDA Receptor Kainate Receptor

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Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

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CA CA I CA Ⅱ CA IX CA XII

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

Molecular Weight

345.32

Formula

C613C6H21NO8S
Unlabeled CAS
SMILES

NS(OC[C@]1(O[13C]([13CH3])([13CH3])O2)[C@@H]2[C@H](O[13C]([13CH3])([13CH3])O3)[C@H]3CO1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (289.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 4 mg/mL (11.58 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8959 mL 14.4793 mL 28.9586 mL
5 mM 0.5792 mL 2.8959 mL 5.7917 mL
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.8959 mL 14.4793 mL 28.9586 mL 72.3966 mL
5 mM 0.5792 mL 2.8959 mL 5.7917 mL 14.4793 mL
10 mM 0.2896 mL 1.4479 mL 2.8959 mL 7.2397 mL
DMSO 15 mM 0.1931 mL 0.9653 mL 1.9306 mL 4.8264 mL
20 mM 0.1448 mL 0.7240 mL 1.4479 mL 3.6198 mL
25 mM 0.1158 mL 0.5792 mL 1.1583 mL 2.8959 mL
30 mM 0.0965 mL 0.4826 mL 0.9653 mL 2.4132 mL
40 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8099 mL
50 mM 0.0579 mL 0.2896 mL 0.5792 mL 1.4479 mL
60 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2066 mL
80 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9050 mL
100 mM 0.0290 mL 0.1448 mL 0.2896 mL 0.7240 mL
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Topiramate-13C6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topiramate-13C6McN 4853-13C6 RWJ 17021-13C6Isotope-Labeled CompoundsPotassium ChanneliGluRSodium ChannelGABA ReceptorCarbonic AnhydraseCalcium ChannelKcsAIonotropic glutamate receptorsNa channelsNa+ channelsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorCarbonate dehydrataseCa2+ channelsCa channelsInhibitorinhibitorinhibit

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