2. GPCR/G Protein Immunology/Inflammation Apoptosis Protein Tyrosine Kinase/RTK Stem Cell/Wnt PI3K/Akt/mTOR Cytoskeleton
  3. CXCR Apoptosis VEGFR GSK-3 Cadherin Caspase
  4. Nef-M1

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer.

For research use only. We do not sell to patients.

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Nef-M1 Chemical Structure

Nef-M1 Chemical Structure

CAS No. : 860401-80-5

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Nef-M1 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis inducer derived from a myristoylated protein encoded by the nef gene in HIV. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT). Nef-M1 activates the apoptosis pathway by increasing the level of caspase-3 in cancer cells. Nef-M1 simultaneously inhibits VEGF-A, p-GSK-3β and vimentin, and enhances E-cadherin, thereby inhibiting angiogenesis and EMT processes. Nef-M1 can be used in the study of colorectal cancer and breast cancer[1][2].

IC50 & Target

SDF-1α-CXCR4

 

VEGFR1

 

Caspase 3

 

GSK-3β

 

Molecular Weight

1177.29

Formula

C50H76N14O17S
CAS No.
Sequence

Thr-Asn-Ala-Ala-Cys-Ala-Trp-Leu-Glu-Ala-Gln
Sequence Shortening

TNAACAWLEAQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nef-M1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nef-M1860401-80-5CXCRApoptosisVEGFRGSK-3CadherinCaspaseCXC chemokine receptorsC-X-C motif chemokine receptorsVascular endothelial growth factor receptorGlycogen synthase kinase-3Glycogen synthase kinase 3Inhibitorinhibitorinhibit

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