2. Membrane Transporter/Ion Channel Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. GABA Receptor ERK
  4. CLH304a

CLH304a  (Synonyms: (E)-GABAB receptor antagonist 1)

Cat. No.: HY-129636
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CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor.

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CLH304a

CLH304a Chemical Structure

CAS No. : 1611483-29-4

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CLH304a Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor[1][2].

In Vitro

(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CLH304a Related Antibodies
Molecular Weight

304.38

Formula

C18H24O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(/C=C/C1=CC(C(C)(C)C)=C(C(C(C)(C)C)=C1)O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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CLH304a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLH304a1611483-29-4(E)-GABAB receptor antagonist 1GABA ReceptorERKGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorExtracellular signal regulated kinasesGABABnegative allosteric modulatorNAMIP3mGluR1mGluR2mGluR5GB2ERK1/2Inhibitorinhibitorinhibit

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