(−)-Epigallocatechin Gallate-d₃/d₄  (Synonyms: EGCG-d₃/d₄; Epigallocatechol Gallate-d₃/d₄)

(-)-Epigallocatechin Gallate-d₃/d₄ (EGCG-d₃/d₄) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

461.39 (for d3)

EGCG-d₃/d₄; Epigallocatechol Gallate-d₃/d₄

C₂₂H₁₅D₃O₁₁ (for d3)

989-51-5

OC(C(O)=C1[2H])=C(C=C1[C@H]2OC(C=C(C=C3O)O)=C3C[C@H]2OC(C4=C(C(O)=C(C(O)=C4[2H])O)[2H])=O)O.OC(C(O)=C5[2H])=C(C([2H])=C5[C@H]6OC(C=C(C=C7O)O)=C7C[C@H]6OC(C8=C(C(O)=C(C(O)=C8[2H])O)[2H])=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. De Amicis F, et al. Epigallocatechin gallate inhibits growth and Epithelial-to-Mesenchymal Transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Apr 1.  [Content Brief]

  [2]. Peeters TH, et al. Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. Cancer Metab. 2019 May 20;7:4.  [Content Brief]

  [3]. Jin H, et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53.  [Content Brief]

  [4]. Tsukasa Tominari; Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015 Jun 12;5:522-7.  [Content Brief]