TCF3 / E2A Antibody (YA4819)

TCF3 / E2A Antibody (YA4819) is a mouse-derived and non-conjugated monoclonal antibody, targeting to E2A. It can be applicated for WB, FC, ELISA assays, in the background of human.

E2A is a transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (MET) (by similar). It forms heterodimers with tissue-specific basic helix-loop-helix (bHLH) proteins, playing key roles in determining tissue-specific cell fate during embryogenesis, such as muscle or early B-cell differentiation (by similar). Together with TCF15, it is required for mesenchymal to epithelial transition (by similar). The dimers bind DNA at E-box motifs (5'-CANNTG-3') (by similar) and also recognize the kappa-E2 site in the kappa immunoglobulin gene enhancer. Additionally, it binds to short DNA sequences IEB1 and IEB2 in the insulin gene transcription control region (by similar) and facilitates ATOH7 binding to the consensus sequence 5'-CAGGTG-3', positively regulating transcriptional activity.

P15923

Predicted band size: 68 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000

WB, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human E2A expressed in E. Coli.