2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis Cell Cycle/DNA Damage
  3. Biochemical Assay Reagents Reactive Oxygen Species (ROS) Mitochondrial Metabolism Apoptosis HSP Bcl-2 Family
  4. Glutamic acid sodium salt

Glutamic acid sodium salt  (Synonyms: Monosodium glutamate)

Cat. No.: HY-W250122 Purity: 99.23%
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Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders.

For research use only. We do not sell to patients.

Glutamic acid sodium salt Chemical Structure

Glutamic acid sodium salt Chemical Structure

CAS No. : 32221-81-1

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Based on 1 publication(s) in Google Scholar

Glutamic acid sodium salt Related Antibodies

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Description

Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders[1][2][3][4][5][6][7][8].

IC50 & Target[1][2][3][4][5][6][7][8]

HSPA5

 

Bcl-2

 

In Vitro

Monosodium glutamate (20 mM; 12-24 h) induces apoptotic cell death in C6 astrocytic cells by promoting reactive oxygen species generation, glutathione depletion, mitochondrial dysfunction, and endoplasmic reticulum stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glutamic acid sodium salt Related Antibodies

Western Blot Analysis[1]

Cell Line: C6 astrocytic cells
Concentration: 20 mM
Incubation Time: 12 h
Result: Up-regulated protein levels of CHOP, Grp78, and Bcl-2.
In Vivo

Monosodium glutamate (4 g/kg b.w.; s.c.; 3 consecutive days) increases calretinin immunoreactivity in hippocampal neurons of 10-day-old Wistar rats, without changing the density of calretinin-immunopositive cells[2].
Monosodium glutamate (4 mg/g b.w.; i.p.) induces liver and kidney damage in Wistar rats[3].
Monosodium glutamate (8 mg/kg; p.o. via drinking water; 1 month) impairs cognitive behavior in male Swiss albino mice, and its combination with Aspartame (HY-B0361) exacerbates neurotransmitter (dopamine, serotonin) reduction and oxidative stress in the forebrain[4].
Monosodium glutamate (100-500 mg/kg; p.o.; daily for 21 days) induces depressive-like behavior, brain oxidative stress, and elevated liver enzymes in male Swiss mice[5].
Monosodium glutamate (300 mg/kg; p.o.; 21 days) reduces pain threshold and increases brain nitric oxide levels in male NMRI mice, inducing hyperalgesia[6].
Monosodium glutamate (4 g/kg b.w.; s.c.; once daily for 7 consecutive days) induces obesity and insulin resistance in female ICR mice[7].
Monosodium glutamate (0.5%-5% in diet or oral gavage) does not affect pulmonary inflammation, Th2 cytokine production, IgE levels, or airway hyperresponsiveness in Ovalbumin-induced asthmatic BALB/c mice[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (225-250 g)[3]
Dosage: 4 mg/g b.w.
Administration: Intraperitoneal injection
Result: Caused turbid swelling, vacuolar degeneration and necrosis in the liver, glomerular compaction and tubular destruction in the kidneys.
Increased serum ALAT, ASAT and lipid peroxidation products (MDA, 4-HDA).
Molecular Weight

169.11

Formula

C5H8NNaO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(C(O)=O)N)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1478.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9133 mL 29.5666 mL 59.1331 mL
5 mM 1.1827 mL 5.9133 mL 11.8266 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.9133 mL 29.5666 mL 59.1331 mL 147.8328 mL
5 mM 1.1827 mL 5.9133 mL 11.8266 mL 29.5666 mL
10 mM 0.5913 mL 2.9567 mL 5.9133 mL 14.7833 mL
15 mM 0.3942 mL 1.9711 mL 3.9422 mL 9.8555 mL
20 mM 0.2957 mL 1.4783 mL 2.9567 mL 7.3916 mL
25 mM 0.2365 mL 1.1827 mL 2.3653 mL 5.9133 mL
30 mM 0.1971 mL 0.9856 mL 1.9711 mL 4.9278 mL
40 mM 0.1478 mL 0.7392 mL 1.4783 mL 3.6958 mL
50 mM 0.1183 mL 0.5913 mL 1.1827 mL 2.9567 mL
60 mM 0.0986 mL 0.4928 mL 0.9856 mL 2.4639 mL
80 mM 0.0739 mL 0.3696 mL 0.7392 mL 1.8479 mL
100 mM 0.0591 mL 0.2957 mL 0.5913 mL 1.4783 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glutamic acid sodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glutamic acid32221-81-1Monosodium glutamateBiochemical Assay ReagentsReactive Oxygen Species (ROS)Mitochondrial MetabolismApoptosisHSPBcl-2 FamilyHeat shock proteinsbiochemical assayreagentInhibitorinhibitorinhibit

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