2. PROTAC Anti-infection
  3. PROTACs HIV
  4. FC-14367

FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS. (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

For research use only. We do not sell to patients.

FC-14367 Chemical Structure

FC-14367 Chemical Structure

CAS No. : 3066893-65-7

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FC-14367 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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HIV HIV-1 HIV-2

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Description

FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS[1]. (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

IC50 & Target

HIV-1

 

Molecular Weight

740.18

Formula

C38H35ClFN7O6
CAS No.
SMILES

O=C1NC(C(CC1)N2C(C3=C(C2)C(OCC(N4CCC(CC4)C5=NN(C6=NC7=C(N6)C=CC(Cl)=C7)C(O)=C5CCC8=CC=C(C=C8)F)=O)=CC=C3)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FC-14367 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FC-143673066893-65-7FC14367FC 14367PROTACsHIVHuman immunodeficiency virusPROTACHIV-1 Nef proteinHIV infectionAIDSInhibitorinhibitorinhibit

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