2. JAK/STAT Signaling PROTAC Protein Tyrosine Kinase/RTK
  3. EGFR PROTACs
  4. PROTAC EGFR degrader 13

PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-14658); Black: linker (HY-W262798); E3 ligand + linker: HY-W998306).

For research use only. We do not sell to patients.

PROTAC EGFR degrader 13 Chemical Structure

PROTAC EGFR degrader 13 Chemical Structure

CAS No. : 2861227-35-0

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PROTAC EGFR degrader 13 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC EGFR degrader 13 (compound 106) is an EGFR PROTAC degrader with a DC50 of <0.1 μM. PROTAC EGFR degrader 13 has proliferation inhibitory activity on cell Ba/F3-TEL-EGFR-T790M-L858R-C797S with an IC50 of 15.6 nM. PROTAC EGFR degrader 13 can be used for the study of EGFR-related diseases such as cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-14658); Black: linker (HY-W262798); E3 ligand + linker: HY-W998306)[1].

Molecular Weight

1004.91

Formula

C49H55BrN11O6P
CAS No.
SMILES

O=C1C2=CC=C(N3CCN(CC4CCN(CC4)C5=C(C6=CN(C)N=C6)C=C(NC7=NC=C(C(NC8=CC=C(C9CC9)C=C8P(C)(C)=O)=N7)Br)C(OC)=C5)CC3)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EGFR degrader 13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 132861227-35-0PROTAC EGFR degrader13PROTAC EGFR degrader-13EGFRPROTACsEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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PROTAC EGFR degrader 13
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