CD169 Antibody (YA4477)

CD169 Antibody (YA4477) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD169. It can be applicated for ICC/IF, FC, ELISA assays, in the background of human.

CD169 is a macrophage-restricted adhesion molecule that mediates sialic-acid-dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells, and CD8 T-cells. It plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for adaptive immune responses. CD169 also mediates the uptake of various enveloped viruses via sialic acid recognition, inducing the formation of intracellular compartments filled with virions (VCCs), thereby enhancing macrophage-to-T-cell transmission of viruses such as HIV-1 or SARS-CoV-2. It acts as an endocytic receptor mediating clathrin-dependent endocytosis and preferentially binds to alpha-2,3-linked sialic acid (by similarity: binds to SPN/CD43 on T-cells). Additionally, CD169 may play a role in hemopoiesis and inhibits antiviral innate immunity by promoting TBK1 degradation via TYROBP- and TRIM27-mediated ubiquitination. In microbial infections, it facilitates viral cytoplasmic entry into activated dendritic cells by recognizing sialylated gangliosides on viral membranes.

Q9BZZ2

Predicted band size: 183 kDa; Observed band size: 220 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human

IF: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

ICC/IF, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CD169 (AA: extra 20-197) expressed in E. Coli.