2. Oligonucleotides
  3. Cap Analogs

Cap Analogs

The “cap” structure (m7G[5']ppp[5']N, where N is any nucleotide) is present at the 5-end of eukaryotic mRNA molecules synthesized by RNA polymerase II. It typically consists of a 7-methylguanosine moiety attached via a 5-5 triphosphate bridge to the 5-terminal nucleoside of the RNA strand. The distinct cap structure plays a vital role in providing resistance to 5′‐exonuclease that helps to protect the mRNA from speedy degradation by 5′‐exonuclease activity. It has participated in numerous aspects of mRNA metabolism such as intracellular transport, splicing, subcellular localization, initiation of RNA, translation, and mRNA turnover. The use of the synthetic dinucleotide analog m7G[5']ppp[5']G has been the most common method for in vitro synthesis of 5-capped mRNAs. The presence of cap structure confers mRNA stability and enables efficient translation.

Cap Analogs (31):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-145974A
    m7GpppAmpG ammonium 99.50%
    m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research.
    m7GpppAmpG ammonium
  • HY-139100B
    m7G(5')ppp(5')A diammonium 75252-10-7 99.15%
    m7G(5')ppp(5')A (m7GpppA) diammonium is a dinucleotide cap analog that can be used for in vitro RNA transcription.
    m7G(5')ppp(5')A diammonium
  • HY-145973A
    3'OMe-m7GpppAmpG (ammonium) solution (100mM) ≥99.0%
    3'OMe-m7GpppAmpG ammonium solution (100mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.
    3'OMe-m7GpppAmpG (ammonium) solution (100mM)
  • HY-153108
    3'-O-Me-m7G(5')ppp(5')A solution (100mM) 99.62%
    3'-O-Me-m7G(5')ppp(5')A (ARCA cap) solution (100mM), anti-reverse cap analog, has a special RNA cap structure. Is a common feature of the mRNA of some RNA viruses and eukaryotes. RNA cap structures serve as signals for translation initiation.
    3'-O-Me-m7G(5')ppp(5')A solution (100mM)
  • HY-145975A
    m7Gpppm6AmpG (ammonium) solution (100mM) 98.84%
    m7Gpppm6AmpG ammonium solution (100mM) is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG ammonium can be used for RNA synthesis in vitro.
    m7Gpppm6AmpG (ammonium) solution (100mM)
  • HY-145969
    β-S-ARCA 1093268-63-3
    β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines.
    β-S-ARCA
  • HY-164190
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium
  • HY-164188
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG triammonium 98%
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium is a Cy5-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy5 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG triammonium
  • HY-145969A
    β-S-ARCA triammonium 99.48%
    β-S-ARCA (triammonium) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNA incorporating β-S-ARCA (triammonium) can prolong cellular half-life and increase protein expression. β-S-ARCA (triammonium) can be used in research of mRNA-based anti-cancer vaccines.
    β-S-ARCA triammonium
  • HY-139100
    N7-Methyl-guanosine-5'-triphosphate-5'-adenosine 62828-63-1
    N7-Methyl-guanosine-5'-triphosphate-5'-adenosine (m7GpppA) is a dinucleotide cap analog that can be used for in vitro RNA transcription.
    N7-Methyl-guanosine-5'-triphosphate-5'-adenosine
  • HY-158772
    m7G(5')ppp(5')(2'OMeA)pU ammonium 99.6%
    m7G(5')ppp(5')(2'OMeA)pU ammonium is a cap analog that can be used for in vitro transcription of mRNA.
    m7G(5')ppp(5')(2'OMeA)pU ammonium
  • HY-139098
    7-Methyl-diguanosine triphosphate 62828-64-2
    7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that can incorporated into mRNA. 7-Methyl-diguanosine triphosphate is involved in translation and mRNA degradation in mammalian cells.
    7-Methyl-diguanosine triphosphate
  • HY-145973
    3'OMe-m7GpppAmpG 2089461-55-0
    3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.
    3'OMe-m7GpppAmpG
  • HY-145975
    m7Gpppm6AmpG 71340-22-2
    m7Gpppm6AmpG is a trinucleotide mRNA 5’ cap analogs. m7Gpppm6AmpG can be used for RNA synthesis in vitro.
    m7Gpppm6AmpG
  • HY-145977
    m7GpppGmpG 1258049-00-1
    m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
    m7GpppGmpG
  • HY-145977A
    m7GpppGmpG ammonium
    m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
    m7GpppGmpG ammonium
  • HY-145979
    m7GpppUmpG 2638447-87-5
    m7GpppUmpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppUmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppUmpG
  • HY-145980
    m7GpppUpG 2638447-85-3
    m7GpppUpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppUpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppUpG
  • HY-145981
    m7GpppCpG 2638447-78-4
    m7GpppCpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppCpG
  • HY-145982
    m7GpppCmpG 2089461-56-1
    m7GpppCmpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppCmpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppCmpG