d-KLA Peptide-d₃₀  (Synonyms: D-(KLAKLAK)2-d₃₀)

d-KLA Peptide-d₃₀ (D-(KLAKLAK)2-d₃₀) is the deuterium labeled d-KLA Peptide (HY-P10285). d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1554.18

C₇₂H₁₀₈D₃₀N₂₀O₁₅

286380-05-0

d-{Lys-{Leu-d10}-Ala-Lys-{Leu-d10}-Ala-Lys-Lys-{Leu-d10}-Ala-Lys-Leu-Ala-Lys}

d-{K-{Leu-d10}-AK-{Leu-d10}-AKK-{Leu-d10}-AKLAK}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32(22): 5262-5268.  [Content Brief]

  [2]. Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6(3): 971-977.  [Content Brief]