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  4. Monoclonal Antibodies Recombinant Antibodies
  5. CTNNA1 Antibody (YA2057)

CTNNA1 Antibody (YA2057)

Cat. No.: HY-P82312
User Guide for Antibodies Technical Support

CTNNA1 Antibody (YA2057) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2057), targeting CTNNA1, with a predicted molecular weight of 100 kDa (observed band size: 100 kDa). CTNNA1 Antibody (YA2057) can be used for WB, IP experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock Quantity
10 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
50 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
100 μL Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

CTNNA1 Antibody (YA2057) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2057), targeting CTNNA1, with a predicted molecular weight of 100 kDa (observed band size: 100 kDa). CTNNA1 Antibody (YA2057) can be used for WB, IP experiment in human, mouse, rat background.
Background

CTNNA1 is a protein that associates with the cytoplasmic domain of various cadherins. Its binding to cadherins forms a complex linked to the actin filament network, which is crucial for the cell-adhesion properties of cadherins. CTNNA1 can interact with both E-cadherin and N-cadherin. Initially thought to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the connection between cadherins and the actin cytoskeleton at adherens junctions, later studies revealed that cortical actin is more dynamic than E-cadherin/catenin complexes, and CTNNA1 does not bind to F-actin within the complex, suggesting an alternative linkage mechanism between actin and adherens junction components. The homodimeric form of CTNNA1 may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for actin filament binding. It is also involved in the regulation of WWTR1/TAZ, YAP1, and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity) and may play a critical role in cell differentiation.
Gene ID
SwissProt ID
Synonyms
Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13
Molecular Weight

Predicted band size: 100 kDa; Observed band size: 100 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Cell Biology
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse, Rat
Dilution Ratio

WB: 1/500-1/1000;IP: 1/20
Application

WB, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human alpha 1 Catenin
Database

Entrez Gene: 1495 Human ; 12385 Mouse ; 307505 Rat

SwissProt: P35221 Human ; P26231 Mouse ;

OMIM: 608970 Human

Documentation
User Guide for Antibodies (1077 KB)

CTNNA1 Antibody (YA2057) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CTNNA1 Antibody (YA2057)
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